Personalized Internet radio provider Stitcher raises $10 million (Appolicious)

In an effort to further bring radio into the 21st century, web-based personalized radio provider Stitcher also available for iPhone) has secured $10 million in Series C funding, thanks to New Enterprise Associates, Benchmark Capital, New Atlantic Ventures and others. The company has now gathered a total investment of $18.7 million in three rounds of funding.

Rather than turn to individual streaming apps of content providers such as CNN and NPR, this free app, available on Android iPhone, BlackBerry and Palm devices, gives users the opportunity to use one central hub to switch between many different programs. Talk, sports, news, entertainment and comedy radio programs are all available on the app, giving users a radio stream on-the-go that does not require additional updates or syncing. Through Stitcher, radio programs are updated automatically and continuously with the most recent episodes and content.

?Stitcher has created for talk radio what Pandora, Spotify, and others have built for music,? said Ravi Viswanathan, general partner at NEA, who will join the company?s board of directors. ?They've made it personalized; they've made it mobile; and they've made it available when and where people want it.? He noted that talk programming in terrestrial radio has spurred a $5 billion advertising market, meaning there is a tremendous opportunity on which to capitalize when it comes to mobile talk radio.

The company plans to use the latest funding to expand its workforce, boost product development and enhance partnerships with content providers, allowing it to expand beyond the more than 6,000 different shows it already streams.

Source: http://us.rd.yahoo.com/dailynews/rss/enterprise/*http%3A//us.rd.yahoo.com/dailynews/external/appolicious_rss/rss_appolicious_tc/http___www_androidapps_com_articles9546_personalized_internet_radio_provider_stitcher_raises_10_million/43035702/SIG=13feue2cj/*http%3A//www.androidapps.com/tech/articles/9546-personalized-internet-radio-provider-stitcher-raises-10-million

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5 Issues A Cover Letter Can Show That A Resume Can't

Lately, the specialist cover letter has taken a backseat to its a great deal more popular cousin, the resume. Despite the fact that it will be usually noticed as stuffy, antiquated, and even frivolous, the cover letter basically has the electrical power to establish the all-important first impression. And what you place in that letter could possibly be the catalyst that sets you apart and will get you an interview.Though a great deal of buyers underestimate the relevance of a cover letter, a single explanation is due to the fact most don?t genuinely know what goes into it. It?s literally an incredible area to catch a hiring manager?s attention and showcase details that just can?t be communicated at the same time within a resume.Like a resume, a cover letter can provide highlights of one?s job accomplishments, a quick summary of the career path, along with your related abilities required for your placement. But, what can a cover letter make an employer see about you that a resume oftentimes can?t?1. Your capacity to promote on your own. Although a resume is the place you promote your knowledge and experiences, an incredible destination to offer by yourself like a powerful investment is inside the cover letter. This isn?t just for those of you in product sales ? all people is anticipated to sell themselves! Being able to achieve this shows you happen to be assertive and assured about your skills. Get the time to create a compelling opening paragraph and hook the hiring manager or recruiter suitable away!two. Your good reasons for position gaps or choppy deliver the results background. You could have taken time off give good results to go back to college or care for an ill relative, but that is not a little something readily explained (or applicable to state) within a resume. A brief, concise paragraph may want to provide sincere, nevertheless tactful answers into any questions in regards to the chronology of your respective give good results historical past.three. Your good reasons for in search of a brand new position. Unless you?re unemployed, giving a cause why you are hunting for any new work is often insightful for an employer. There isn?t any need to go into detail or badmouth your current/past employer, but a straightforward statement about seeking to grow in your own area or transform your career route could be enough. This statement is particularly useful once you possess a different circumstance driving your employment search.4. Your explanations for altering careers (if relevant). If you happen to have invested 20 many years in investment banking are now pursuing a career in teaching, the hiring manager?s primary question would be, ?Why the modify?? Offering some insight will give them viewpoint about you and in which you might be career-wise. Not explaining your causes for changing careers could even make an employer believe you?re desperate to utilize for any previous work (even those not with your field), or even worse nevertheless, make them assume you accidentally applied for that incorrect employment!5. Your persona! Unless they are professionally written, most resumes are uninteresting, typical, and display tremendously little character. Employers are keen on not just your laborious knowledge, but additionally your capability to excite, collaborate, motivate, promote, develop, lead, and expand. What more beneficial solution to present you could have these capabilities than inside language you use with your cover letter? Let your true personality arrive out in your own cover letter and it should complement the proficiency and experiences you showcase in your own resume.Also for the over, a cover letter may be a good spot to existing client/colleague testimonials or give qualifications specifics about a corporate award you earned. These are just some factors why a cover letter shouldn?t be looked at as a much less favored cousin to your resume, but rather an equal and complementary associate, assisting to determine you because the most desirable candidate for your job!?

Jimmy Sweeney Cover Letters

Use Jimmy Sweeney Cover Letters to get that job. Jimmy sweeney cover letters.

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Filed under: Home Based Business ? Tags: amazing cover letter creator, amazing cover letters, cover letter creator, jimmy sweeney cover letters, jimmy sweeneys cover letters

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Tampa Bay International Business Council - USF AMA

Tampa Bay International Business Council

Tampa Bay International Business Council?s is having their fall event and they at least need 6 volunteers

The event is October 12th from 5:30 p.m. to 8:30 p.m. at Brio (Restaurant) at the International Plaza. Need assistance with registration and assisting guests. For more information on it you can go to http://www.tbibc.org/.? 200 professionals are expected to attend this event.? Free food and cash bar. Contact: ?Zongde Li (zli7@mail.usf.edu).

Source: http://www.usfama.com/tampa-bay-international-business-council/

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Jane Lynch not sure she wants to host Emmys again (AP)

NEW YORK ? Just days after hosting her first Emmy Awards, actress Jane Lynch says she's not sure she'd do it again.

Lynch said in an interview Wednesday that if she had to decide now, her answer would be no. But she says she had a great time and hadn't felt "that creative and alive in a long time."

Her Emmy performance Sunday received mixed reviews.

The actress is promoting her new memoir, "Happy Accidents," and "Glee." Lynch plays glee-club-hating cheerleading coach Sue Sylvester on the hit Fox series, which premiered its third season Tuesday.

Lynch says she's looking forward to spending time with her family now that the Emmys are over. She married Lara Embry last year and is stepmother to Embry's 9-year-old daughter, Haden.

Source: http://us.rd.yahoo.com/dailynews/rss/celebrity/*http%3A//news.yahoo.com/s/ap/20110921/ap_en_tv/us_people_jane_lynch

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Techniques in Becoming an Effective ... - Computer Technology News

Computers and the Internet have come a long way since their inception. Living in the computer age means adapting to new technologies as they evolve. The ease and speed of communication that computer technology provides allows us to be more productive in every facet of our lives. That technology requires skilled computer professionals to design, maintain, and implement it.

Computer training is divided into specialties including:
? Computer hardware
? Computer software
? Computer networking
? Web Development

Computer hardware refers to the actual physical components that comprise computers (processors, modems, keyboards, motherboards etc). Computer hardware engineers design, develop and maintain computer hardware. They may oversee the installation and manufacture of hardware. Due to the constant flux of the industry, continued education is required to keep up with trends and technology.

Computer software refers to the content that makes a computer work. Software is divided into three categories: Platform (such as operating systems i.e. Windows, Linux, and Macintosh OSX), Applications (Microsoft Office, games), and User-Written (templates, plug-ins, extensions). Computer software engineers, like their hardware counterparts, are required to continually learn new skills in conjunction with developing technology.

Computer networking refers to communication between a group or groups of computers. This includes LAN-local area network, MAN-metropolitan area network and WAN-wide area network. Computer network engineers work with software and hardware integration across a system of computers and servers. They deal with computer-to-computer interface and connect users to each other via private as well as public networks.

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Web development refers to the building and implementation of websites (design, programming, server configuration) ? Web page design is a subset that deals with user interface design, graphics, html and CSS (cascading style sheets). Web page designers are behooved to have good art skills as they will most likely be dealing with graphics, layout and Flash applications.

Other than the obvious passion for computers and technology, salary and job growth potential are excellent reasons to consider computer careers. Diversity of computer skills adds to marketability in the workforce. Many employers do not have time to train workers on basic skills and expect employees to be more than familiar with computers.

If you have an aptitude or interest in math, science or art, and have strong problem solving and analytical skills you are a perfect candidate for a computer related career. Computer careers can be solitary work, but often require good communication skills. Systems administrators must know how to relay information to clients and coworkers in order to maintain order and efficiency in the system.

Education is available in many varieties; from certifications, certificate programs, associate?s degree programs, bachelor?s and even master?s degree programs. Many professionals receive degrees in computer science and related fields, but still others are required to have specific certifications (for example MCSE-Microsoft Certified Systems Engineer or MCSA-Microsoft Certified Systems Administrator). Many industries do not require these specific certifications, only knowledge and experience of computer systems. When making a decision about education, research the jobs that interest you and find out just what the employers are looking for in a candidate. Why spend four years working on a bachelor?s degree when a shorter certificate program may be all you need?

.

For more information on careers, training, and working conditions see the Occupational,

?

Source: http://www.revolution-embedded.com/2011/09/techniques-in-becoming-an-effective-pc-repair-technician/

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How to Reset A PS2 Game System | Oval Egg Articles

This article sheds a little light on "How to Reset A PS2 Game System". It's just nowadays that people are beginning to know about Console Systems, discussing it on much larger level. Before this topic was not that talked about. Primarily because people associated with the topic did not do enough. Acquire thorough benefit of invaluable knowledge in this article and please take time to appreciate it totally instead of just skimming through it.

This article is work of Abraham David. If you would like to take this write-up please link back to this page. Article on "How to Reset A PS2 Game System" starts after this.

Article Starts from Here:

In the gaming console industry, Sony is one of the leading gaming console designer and manufacturer today. It has a wide library of games unlike other consoles and they also have the latest technology in sound and graphics integrated in their gaming console.

In the past, Sony has designed a game console called PlayStation 1 or PS1. After the success of this gaming console, Sony again designed one of the best gaming console that hit the gaming console market. They designed the PlayStation 2 or PS2. Like the PS1, the PS2 has a great variety of games. With a sleek design and great games, PS2 became one of the most popular and widely bought gaming consoles in the world.

Games for PlayStation 2 are readily available in the market today. There are games for all ages, sport games, and even games for mature persons filled with realistic environment and characters and even features that depicts realism, such as violence, blood and gore. The characters in the games are also designed to move like real people.

When people buy a PlayStation 2 gaming console, people just rip it out of the box without even reading the user manual. People do this because they want to play with their new PlayStation 2 gaming console immediately after purchasing it. However, there are different things you should consider when setting up the PlayStation 2 gaming console. You need to remember that PlayStation 2 is entirely different from other gaming console that you may have played with in the past, such as the PlayStation 1.

Of course, you need to know the different features of PlayStation 2 in order for you to properly maintain it in a good working condition. You also have to know how to set it up to avoid frustration.

People who don?t read the user manual because of rushing in on playing their new PlayStation 2 gaming console doesn?t know how to reset it or how to put their gaming console on stand-by mode. They will either usually let the system run for hours or completely shut the system down by unplugging it.

The PlayStation 2 has a reset button located in front of the console. But, you need to read the user manual to locate it. The reset button has two functions, the first is to reset the gaming console and the second function is to put it in stand-by mode.

By pressing the stand-by button for a couple of seconds, you will turn the system on stand-by mode. It doesn?t necessarily turn it off, but it only puts it in stand-by mode. If you leave the system on or completely shut down the PlayStation 2 gaming console, you will likely have a problem with maintenance. Letting it run for hours or shutting it down by pulling the power plug will cause your PlayStation 2 to malfunction.

This is why it is important for you to put your PlayStation 2 gaming console in stand-by mode when you are not using it.

Warning: Anything within this composition is personal opinion of its writer on "How to Reset A PS2 Game System", you have to do your own research to come up with proper facts. Proper consultant on "How to Reset A PS2 Game System" should be consulted before taking any action. OvalEgg.com is not responsible for any damages of any kind that may arise from applying information contained in this article.

Many people have found that a PlayStation 2 gaming console should be more user friendly for beginners. They feel that Sony should label the reset button with a stand-by label to make it easier for people to use.

It is a fact that many people who have bought PlayStation 2 gaming console neglect to read the instruction manual on how to set-up it up. This is why many first-time users find hard to set it up and how to turn it off. The cables are also questioned. Many people get confused on where to connect the cables and they even suggested that Sony PlayStation 2 should have color coded cables and better labeling to avoid confusion and frustration when setting up the PS2 gaming console.

Unfortunately, Sony will not recall the products they released in the market. So, in order for you to know how to reset the gaming system, you should either read the user manual before setting it up and let it guide you or you can ask advanced PlayStation 2 users on how to reset the PlayStation 2 or put it in stand-by mode.

Always remember that PlayStation 2 is an exceptionally expensive gaming console. This is why you should know how to properly maintain it. So, if you are not using your PS2 put it in stand-by mode by pressing the reset button for a couple of seconds.

When properly maintained, you can expect to play with your PS2 for years to come.

Thanks for reading this write-up. You have to link to this page if you want to take this article any function. I hope you liked what I wrote on "How to Reset A PS2 Game System". I would be delighted to know what you think concerning it, negative or optimistic. Please put down a comment below and show me you're alive.

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The Los Angeles River: Kayaking a Forgotten Waterway (Time.com)

As we kayaked, red-tailed hawks circled above us looking for food and snowy egrets played along the banks. A cormorant dived into the water next to me and leaped back to the surface just inches in front of my kayak. On a beach behind a small eddy, a fisherman angling for carp and bass caught a foot-long specimen and reeled it in for lunch. Yellow sticky monkey flowers poked out through glades of tall willows, sycamores and cottonwoods that hung over water where dragonflies hovered. Welcome to the Los Angeles River, in the middle of the San Fernando Valley in the city of Los Angeles.

"The L.A. what?" Ask people on the streets of Los Angeles about the city's river, and you'll get some strange looks. Some won't even know the city has one. Others will know it as a trickle of water and illegally dumped chemicals confined by graffiti-strewn concrete walls, because that's what they see from the freeways that pass over it. Still others envision a favorite burial ground for rusted shopping carts, old mattresses and refrigerators. (See TIME's photos of the Los Angeles River.)

True, the 51-mile waterway ? which stretches from Canoga Park through the valley, past Griffith Park and downtown Los Angeles on its way to Long Beach, where it lets out into the Pacific Ocean ? is mostly locked by concrete. But there are several "soft-bottom" sections that resemble what the entire river once looked like. This summer, for the first time in nearly a century, Angelenos were legally allowed to paddle down one part of the river.

For Native Americans and early Spanish settlers, the waterway was a free-flowing source of drinking water that provided them a livelihood. But when Los Angeles grew, it didn't go the route of other U.S. cities that made their rivers a central landmark, lining them with parks and bike paths. After floods hit in the 1930s, authorities decided they needed to protect nearby homes, and they enclosed the river with concrete and turned it into a flood-control channel. It became a fenced-off no-man's-land operated by the Army Corps of Engineers. Residents weren't allowed to navigate the waters, so they started disassociating from it and even took to using it as an alternate garbage dump.

After years of local environmental groups and naturalists putting pressure on the county and the Army Corps, last year the U.S. Environmental Protection Agency declared the river a "traditional navigable waterway" subject to the protections of the Clean Water Act. That prompted activist and boater George Wolfe to organize an expedition down a soft-bottom section of the river near Griffith Park, which received a lot of local media attention and helped galvanize support for the river. In July, the Army Corps issued a license allowing the Los Angeles Conservation Corps to lead a pilot program down a 1.5-mile section of the river between Balboa and Burbank boulevards, and the Paddle the Los Angeles River program was launched. "I'm no longer this half-crazed maverick boater with the idea of boating down a river most people don't even recognize as a river," Wolfe says. (See how Los Angeles coped during "Carmageddon.")

For Wolfe and environmental groups, opening up the river isn't just about having fun on a kayak. They see the pilot program as a first step toward taking out the concrete and turning the watershed back into a natural, trashless river again. "Think about how L.A. would look if we had a living river. It would be a much different and really a much more splendid city," Melanie Winter, director of the group the River Project, said as we drifted down the waterway. "Just because we've built out the way we have doesn't mean we can't retrofit to have it back. When you do that, you get parks and better public health and habitat, and you get a soul back in the city again."

That might help bring back respect for the river, which is sorely needed. Despite the sections of idyllic nature, the urban character of the river surfaces constantly. Kayaking down a ledge, my boat became stuck on a rusted shopping cart lurking in the water, and it took me a while to get free. I saw dozens more during the three-hour trip. My kayak sailed through clusters of trash including empty Styrofoam noodle containers, spray-paint cans and vitamin-bottle caps. The noise from airplanes overhead and cars on overpasses above the river spoiled the natural quiet. The water was undoubtedly full of pesticides from storm drains that empty into the waterway. As Ignacio Garcia, one of our guides from the Los Angeles Conservation Corps, put it: "It would be beautiful if there were no trash." In one section of the river, there was a faint but unwelcome smell not unlike sewage. "You get some unique odors around here," said a guide who goes by the name Ranger Tim, after I looked at him with a grimace.

Yet the elements of a real river trip were still there. We navigated around sandbars, portaged around rocky ledges and sailed by high arroyo walls eroded by flood wash. Andy Garcia, 31, who was fishing on a bank, said he often used the river to seek solace from the city. "I come here to relax and take it easy," said Garcia, who was surprised to see kayakers. Indeed, it's an outdoor experience unlike any other in L.A., a city mostly known for beaches, canyons and palm trees. If the pilot paddle program is any gauge, Angelenos seem to want to start treating the watershed as a river again. Tickets for the $50 river expeditions, which last through Sept. 25, sold out in just 10 minutes. "I need a ticket," said one person on the program's Facebook page. "WHAT!!! Sold out already!!" said another.

See TIME's special on intelligent cities.

See a list of the top 10 urban biking paths.

Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//us.rd.yahoo.com/dailynews/external/time_rss/rss_time_us/httpwwwtimecomtimenationarticle08599209258700htmlxidrssnationyahoo/42977520/SIG=12l8jhght/*http%3A//www.time.com/time/nation/article/0,8599,2092587,00.html?xid=rss-nation-yahoo

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Storm Lee threatens Southeast with heavy rains (Reuters)

NEW ORLEANS (Reuters) ? After testing New Orleans' flood defenses over the weekend, Tropical Storm Lee moved northeast on Monday after weakening to a tropical depression, and threatened to bring heavy rains and flooding to a large section of the Southeast.

Moving slowly inland, the powerful rainmaker was on course to hit Mississippi on Monday and Alabama, Tennessee and Kentucky on Wednesday and Thursday, the U.S. National Hurricane center said.

Even as a tropical depression, the remnants of Lee have the potential to dump 10-15 inches of rain across the Gulf region, forecasters said. Heavy rains are expected to spread into the Tennessee Valley and Southern Appalachians through Tuesday with rainfall of 4-8 inches.

"These rains are expected to cause extensive flooding and flash flooding," the hurricane center said. It added that tornadoes were possible on Monday in sections of Louisiana, Mississippi, Alabama and the Florida Panhandle and southwest Georgia.

The rains could bring to the Tennessee Valley and Appalachian Mountains the same kind of flash flooding seen recently in Vermont after Hurricane Irene.

In Texas, winds from the storm whipped up wildfires that have burned more than 3.5 million acres (1.4 million hectares) of the parched state this season, with 1,000 homes threatened in Bastrop County, just east of Austin.

The National Hurricane Center said the remnants of Lee were 55 miles west-southwest of McComb, Mississippi, with maximum sustained winds of 35 mph around 11 p.m. EDT (0300 GMT on Monday). The storm was moving east-northeast at 7 mph.

The storm has temporarily shut over 60 percent of offshore oil production.

In New Orleans, flood defenses appeared to pass one of their biggest tests since Hurricane Katrina devastated the city in 2005 despite up to 13 inches of rainfall since Lee developed late last week.

NEW ORLEANS HOLDS

Half the city lies below sea level and is protected by a system of levees and flood gates.

Some street flooding was reported, but the city's massive pumping system kept ahead of the volume and diverted the waters into Lake Pontchartrain.

New Orleans' levees saw less stress because Lee's winds were too weak to drive a massive storm surge into the city, as was the case during Katrina, which flooded 80 percent of the city, killed 1,500 people and caused more than $80 billion in damage to the popular tourist destination.

New Orleans Mayor Mitch Landrieu warned residents to stay alert for flash floods and high winds expected before Lee departs, saying, "Let's not be lulled to sleep by the breaks that we've had."

There were isolated reports of flooding in roads and homes. No injuries or deaths were reported in Louisiana.

Wet conditions associated with the storm appeared to be a factor in an early morning car wreck in Mobile, Alabama, that killed one man and left several injured.

As of Sunday afternoon, 6,149 customers were without power in Louisiana and 609 in Mississippi, utility Entergy Corp reported.

More than 60 percent of U.S. offshore oil production, all based in the Gulf of Mexico, and over 44 percent of offshore gas production were shut as of Saturday, The U.S. government said. Most of that output should quickly return once the storm passes.

Major offshore producers like Royal Dutch Shell, Exxon Mobil Corp and BP Plc shut down platforms and evacuated staff late last week.

Shell, Exxon and Anadarko Petroleum Corp have started to return workers to offshore platforms.

Low-lying refineries in Louisiana that collectively account for 12 percent of U.S. refining capacity were watching the storm closely but reported no disruptions.

In the open Atlantic, Hurricane Katia, which strengthened rapidly to a Category 2 storm on Sunday, had slightly weakened early on Monday and was moving steadily in a northwestward direction about 400 miles north of the northern Leeward Islands, the hurricane center said.

Katia had top sustained winds of 100 mph and was expected to become a "major hurricane" by Tuesday, the hurricane center said. It added that large swells from Katia were expected to affect most of the U.S. East Coast, Bermuda, the Greater Antilles and the Bahamas in the next few days.

(Additional reporting by Kristen Hays in Houston, Tom Brown in Miami, Kelli Dugan in Mobile, Alabama and Jim Forsyth in San Antonio; Writing by Peter Cooney; Editing by Paul Simao)

Source: http://us.rd.yahoo.com/dailynews/rss/weather/*http%3A//news.yahoo.com/s/nm/20110905/ts_nm/us_storm_usa_gulf

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Lung Cancer when Associated with Asbestosis and Mesothelioma is ...

Lung Cancer when Associated with Asbestosis and Mesothelioma is an Occupational Disease

The assertion that asbestosis must be present in order to attribute a lung cancer to asbestos exposure does not meet accepted standards for establishing causation.? One interesting study is called, ?Historical perspectives in occupational medicine. Changing attitudes and opinions regarding asbestos and cancer 1934?1965? by Philip E. Enterline PhD ? American Journal of Industrial Medicine Volume 20, Issue 5, pages 685?700, 1991.? Here is an excerpt: ?Abstract ? Literature published in the years 1934?1965 was reviewed to determine attitudes and opinions of scientists as to whether asbestos is a cause of cancer. In Germany, the issue was decided in 1943 when the government decreed that lung cancer, when associated with asbestosis (of any degree), was an occupational disease. In the United States, however, there was no consensus on the issue until 1964. Opinions of scientists over a 22 year period are shown and the contributions of various cultural, social, economic and political factors to these opinions are discussed. A lack of experimental and epidemiological evidence played a major role in delaying a consensus. Other important factors included a rejection of science conducted outside of the U.S. during this period, particularly a rejection of German scientific thought during and after WWII, and a rejection of clinical evidence in favor of epidemiological investigations. Individual writers rarely changed their minds on the subject of asbestos as a cause of cancer.?

A second study is called, ?Lung cancer and asbestos exposure: Asbestosis is not necessary? ? David Egilman MD MPH, Alexander Reinert ? American Journal of Industrial Medicine ? Volume 30, Issue 4, pages 398?406, October 1996.? Here is an excerpt: ?Abstract ? Recent commentaries on the issue of asbestos-related lung cancer have raised important points. One major question is whether lung cancer can be attributed to asbestos exposure in the absence of asbestosis. This review attempts to place the debate in the proper context for establishing causation. Relevant epidemiologic and pathologic studies are analyzed, as well as the scientific basis for each position in the debate. The assertion that asbestosis must be present in order to attribute a lung cancer to asbestos exposure does not meet accepted standards for establishing causation. In addition, some evidence has been incorrectly cited in support of this position. This discussion can benefit from clearer definitions of asbestosis, a more thorough evaluation of the available scientific information, and a proper context for determining causation. This review of the available evidence indicates that lung cancers can occur as a result of asbestos exposure, in the absence of clinical or histologic asbestosis. Causation in an individual should be assessed by considering duration of exposure, intensity of exposure, and appropriate latency.?

A third study is called, ?Induction of micronuclei, hyperdiploidy and chromosomal breakage affecting the centric/pericentric regions of chromosomes 1 and 9 in human amniotic fluid cells after treatment with asbestos and ceramic fibers? by Elke Doppa,? Maik Schuler, Dietmar Schiffmanna and David A. Eastmond ? Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ? Volume 377, Issue 1, 9 June 1997, Pages 77-87.? Here is an excerpt: ?Abstract ? This article describes the induction of micronuclei, hyperdiploidy and chromosome breakage in human amniotic cells in vitro by amosite, chrysotile and crocidolite asbestos, and ceramic fibers. The response of human (amniotic fluid cells) and rodent (Syrian hamster embryo fibroblasts, SHE) cells to fiber treatment was compared using the micronucleus assay. The data of the rodent studies were taken from a previous investigation (Dopp, E. et al. (1995) Environ. Health Perspect., 103, 268?271). All types of mineral fibers caused a significant increase of micronucleated cells. The kinetochore analysis revealed that all three types of asbestos and ceramic fibers yielded similar effects. Approximately 50% of the induced micronuclei were kinetochore-negative indicating formation through clastogenic events. Human amniotic cells were much less susceptible than SHE cells to the induction of micronuclei by mineral fibers. This again demonstrates that SHE cells are more susceptible to chromosomal changes than human amniotic fluid cells. The application of fluorescence in situ hybridization (FISH) with tandem DNA probes yielded more detailed information about specific structural chromosome aberrations in the 1 (cen?q12) and 9 (cen?q12) regions and about abnormal numbers of chromosomes in interphase human amniotic fluid cells. Using this FISH approach we found a statistically significant increase of chromosomal breakage in the pericentric heterochromatin regions of chromosomes 1 and 9 in interphase human amniotic cells after exposure to asbestos and ceramic fibers compared to control cells. The number of hyperdiploid cells was also significantly increased. Our results show that asbestos fibers as well as ceramic fibers are inducers of structural and numerical chromosomal aberrations in human amniotic fluid cells.?

We all owe a debt of gratitude to these fine researchers for their important work.? If you found any of these excerpts helpful, please read the studies in their entirety.

Related posts:

  1. Asbestosis Lung Cancer and Mesothelioma Rates as a Result of Occupational Asbestos Exposure
  2. Asbestosis Lung Cancer and Mesothelioma Rates as a Result of Occupational Asbestos Exposure
  3. Asbestosis Lung Cancer and Mesothelioma Rates as a Result of Occupational Asbestos Exposure
  4. Asbestos fiber ? Asbestosis, Mesothelioma, Lung Cancer malignancy
  5. Asbestos Disease Lung Cancer 1980 US Navy
  6. Asbestos and Lung Cancer

Source: http://www.cancertips.net/lung-cancer-when-associated-with-asbestosis-and-mesothelioma-is-an-occupational-disease/

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